A Multivariate analysis of Prescribing Information for Next Generation type 2 Diabetes treatments

Treatments for Type 2 Diabetes

G lucagon-like peptide-1 (GLP-1) is produced by the proglucagon gene in L-cells of the small intestine in response to nutrients.1 It is an incretin – a gut hormone – that is responsible for the greater insulin response to oral versus IV glucose.2 Its major mechanism of action occurs through stimulation of glucose-dependent insulin release from the pancreatic islets. In addition to its insulinot...

Novel treatments for type 2 diabetes.

Treatments for Type 2 Diabetes; a Focus on DPP4 Inhibitors

New treatments for diabetes are always exciting in the beginning but as experience grows their position in management becomes less certain. This review focuses on DPP4 inhibitors and their place in management of type 2 diabetes. Although hypoglycaemia is rarely an issue, the effectiveness in reduction in blood sugar is greatest at the higher blood sugar levels, hence much of the value of using ...

Novel Treatments Target Type-2 Diabetes.

Patients with type-2 diabetes can control their blood glucose levels through diet and exercise, by losing excess weight, and by taking medications, such as first-line metformin. We examine several promising drugs in the type-2 diabetes pipeline.

Multivariate Network Meta-Analysis: An Example In Type 2 Diabetes For The Analysis Of Glycaemic Control.

Methods • Network meta-analyses are commonly conducted within a Bayesian framework to enable the ranking of interventions, based on the probability of each treatment to be associated with the best efficacy. • Multivariate models have been developed to deal with correlation between outcomes as they allow to account for the within-study correlation between endpoints. • Moreover, the multivariate ...